Post-doctoral Fellow at MIT, Massachusetts Institute of Technology
nationality
Saudi Arabia
innovation
An in-situ detection and monitoring of mRNA degradation in mRNA vaccines using Deep-UV resonance Raman spectroscopy
Lamyaa's technology utilizes a carefully selected laser beam to penetrate a glass vial and analyze its contents without the need for puncturing the vial or destroying its contents. The laser is specifically tuned to interact with the unique properties of mRNA, allowing us to selectively detect its signal while avoiding interference from lipids, solvents, or the glass container. This innovative approach, based on Raman spectroscopy, provides quick, in-situ monitoring of mRNA integrity directly within its packaging. By eliminating the need for sample extraction, the method ensures a fast, accurate, and non-invasive assessment, making it an optimal solution for safeguarding the quality of sensitive therapeutics, such as mRNA vaccines, during storage and transportation.
Lamyaa's future plans aim to make this technology a standard for ensuring the quality of therapeutics. Initially, we expect it to be adopted in quality control centers to monitor mRNA vaccine integrity during production and distribution. In the longer term, she plans to expand its use to clinical settings, enabling real-time testing of vaccine quality before administration to patients.